Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions

The purpose of this study was to measure apparent diffusion coefficient values of normal liver parenchyma and focal liver lesions utilizing a respiratory gated diffusion sequence with multiple b-values and to investigate whether apparent diffusion coefficient (ADC) measurements may be utilized to ch...

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Bibliographic Details
Published in:European radiology 2008-03, Vol.18 (3), p.486-492
Main Authors: Gourtsoyianni, Sofia, Papanikolaou, Nickolas, Yarmenitis, Spyros, Maris, Thomas, Karantanas, Apostolos, Gourtsoyiannis, Nicholas
Format: Article
Language:English
Subjects:
Abdomen
Adult
Aged
Cysts
Diagnosis, Differential
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Female
Hemangioma
Hepatobiliary-Pancreas
Humans
Imaging
Internal Medicine
Interventional Radiology
Liver cancer
Liver Diseases - diagnosis
Liver Neoplasms - diagnosis
Male
Medicine
Medicine & Public Health
Metastasis
Middle Aged
Neuroradiology
Radiology
Respiration
Ultrasound
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Summary:The purpose of this study was to measure apparent diffusion coefficient values of normal liver parenchyma and focal liver lesions utilizing a respiratory gated diffusion sequence with multiple b-values and to investigate whether apparent diffusion coefficient (ADC) measurements may be utilized to characterize and differentiate between malignant and benign focal hepatic lesions. Thirty-eight consecutive patients underwent MRI of the liver including diffusion-weighted imaging (DWI). A single-shot echo planar imaging sequence was applied in coronal orientation with multiple b-values (0, 50, 500, 1,000 s/mm 2 ) and respiratory gating. ADC values were recorded on corresponding maps utilizing region of interest measurements in patients with benign (group A), malignant (group B) focal lesions and liver parenchyma (group C). Statistical analysis was applied to check whether differences in mean ADC values were significant (p
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-007-0798-4