The significance of variation in extrusion speeds and temperatures on a PEO/PCL blend based matrix for oral drug delivery

The body of work described in this research paper outlines the use of PEO/PCL blends in the production of monolithic matrices for oral drug delivery. Several batches of matrix material were prepared with carvedilol used as the active pharmaceutical ingredient. The matrices were prepared using variou...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2008-03, Vol.351 (1), p.201-208
Main Authors: Lyons, John G., Blackie, Paul, Higginbotham, Clement L.
Format: Article
Language:English
Subjects:
Administration, Oral
Biological and medical sciences
Calorimetry, Differential Scanning
Carbazoles - administration & dosage
Carbazoles - chemistry
Delayed-Action Preparations
Drug delivery
Extrusion
General pharmacology
Matrix
Medical sciences
PCL
PEO
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyesters - chemistry
Propanolamines - administration & dosage
Propanolamines - chemistry
Rheology
Solubility
Technology, Pharmaceutical - methods
Temperature
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The body of work described in this research paper outlines the use of PEO/PCL blends in the production of monolithic matrices for oral drug delivery. Several batches of matrix material were prepared with carvedilol used as the active pharmaceutical ingredient. The matrices were prepared using various extrusion parameters to investigate the effect of screw speed and barrel temperature on the properties of the drug delivery devices. The resultant extrudate was characterised using steady state parallel plate rheometry, differential scanning calorimetry (DSC) and dissolution testing. Higher screw speeds were observed to result in slightly lower matrix melt viscosity when compared with matrices compounded using lower screw speeds. Dissolution testing showed that the incorporation of the hydrophobic PCL polymer into a PEO matrix results in a retarded drug release profile.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2007.09.041