Bioactive glass-derived hydroxyapatite-coating promotes granulation tissue growth in subcutaneous cellulose implants in rats

Granulation tissue was induced in hydroxyapatite-coated cellulose sponges with subcutaneous implantation in rats. A massive inflammatory reaction with an intense foreign body reaction and an increased invasion of fibrovascular tissue was observed by days 1–3 post-operation, whereas tissue growth int...

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Bibliographic Details
Published in:Acta biomaterialia 2008-03, Vol.4 (2), p.354-361
Main Authors: Tommila, Miretta, Jokinen, Jutta, Wilson, Timothy, Forsback, A.-P., Saukko, Pekka, Penttinen, Risto, Ekholm, Erika
Format: Article
Language:English
Subjects:
Animals
Cellulose
Cellulose sponge
Coated Materials, Biocompatible
Durapatite
Extracellular Matrix Proteins - genetics
Glass
Granulation tissue
Granulation Tissue - growth & development
Granulation Tissue - metabolism
Growth factors
Hydroxyapatite-coating
Implants, Experimental
Inflammation
Macrophages - cytology
Male
Materials Testing
Neovascularization, Physiologic
Rats
Rats, Sprague-Dawley
RNA - genetics
RNA - metabolism
Surgical Sponges
Wound Healing
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Summary:Granulation tissue was induced in hydroxyapatite-coated cellulose sponges with subcutaneous implantation in rats. A massive inflammatory reaction with an intense foreign body reaction and an increased invasion of fibrovascular tissue was observed by days 1–3 post-operation, whereas tissue growth into the uncoated control implants was much slower and took place mainly on their surfaces. The foreign body reaction in apatite-coated sponges declined after post-operative day 14, and no obvious differences were seen between the two cellulose sponges from 1 month up to 1 year after implantation. The apatite-coated implants attracted macrophages and fibroblasts, and favored angiogenesis. The excessive connective tissue formation was histologically normal, synthesized the major extracellular matrix molecules in a normal ratio and did not seem to disturb the animals in any way. These results warrant further investigations on clinical applicability of hydroxyapatite-coated cellulose sponges, when fast proliferation of connective tissue is desirable.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2007.07.005