Vitamin D and prevention of breast cancer: Pooled analysis

• Published in: Journal of steroid biochemistry and molecular biology 2007-03, Vol.103 (3-5), p.708-711
• Main Authors: Garland, Cedric F., Gorham, Edward D., Mohr, Sharif B., Grant, William B., Giovannucci, Edward L., Lipkin, Martin, Newmark, Harold, Holick, Michael F., Garland, Frank C.
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Administration, Oral; Biological and medical sciences; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - pathology; Breast Neoplasms - prevention & control; Diet; Dose–response gradient; Enzymes. Coenzymes. Vitamins. Pigments; Epidemiology; Fundamental and applied biological sciences. Psychology; Gynecology. Andrology. Obstetrics; Humans; Incidence; Mammary gland diseases; Medical sciences; Metabolisms and neurohumoral controls; Pooled analysis; Risk Factors; Serum; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D - administration & dosage; Vitamin D - blood; Vitamin D - pharmacology
• ISSN: 0960-0760; 1879-1220
• DOI: 10.1016/j.jsbmb.2006.12.007

Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence and mortality rates of breast cancer in ecological and observational studies, but the dose–response relationship in individuals has not been adequately studied. A literature search for all studies that reported risk by of breast cancer by quantiles of 25(OH)D identified two studies with 1760 individuals. Data were pooled to assess the dose–response association between serum 25(OH)D and risk of breast cancer. The medians of the pooled quintiles of serum 25(OH)D were 6, 18, 29, 37 and 48ng/ml. Pooled odds ratios for breast cancer from lowest to highest quintile, were 1.00, 0.90, 0.70, 0.70 and 0.50 (p trend