Chromogranin A expression correlates with tumour cell type and prognosis in signet ring cell carcinoma of the stomach

Aims:  To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well‐differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. Methods and results:  102 SRCCs were categorize...

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Bibliographic Details
Published in:Histopathology 2008-02, Vol.52 (3), p.305-313
Main Authors: Fujiyoshi, Y, Eimoto, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Signet Ring Cell - metabolism
Carcinoma, Signet Ring Cell - mortality
Carcinoma, Signet Ring Cell - pathology
chromogranin A
Chromogranin A - metabolism
Combined Modality Therapy
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
neuroendocrine differentiation
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prognosis
signet ring cell carcinoma
stomach
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival Rate
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Summary:Aims:  To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well‐differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. Methods and results:  102 SRCCs were categorized into five subtypes according to the predominant cell type in the World Health Organization classification. 38 cases (37.3%) showed focal or diffuse CgA positivity. The positive cells were mostly histiocytoid and eosinophilic SRCC cells and some were classical SRCC cells. Small cell and anaplastic‐type SRCC cells were only rarely immunopositive. There was no significant relationship between CgA expression and the extent of invasion or presence of metastasis. However, a significant positive correlation existed between CgA positivity and favourable prognosis, with a tendency for greater positivity to be associated with better overall survival. Multivariate analysis showed expression of CgA to be an independent prognostic factor. Conclusion:  CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2007.02950.x