Lipoprotein Associated Phospholipase A2 Inhibition Reduces Generation of Oxidized Fatty Acids: Lp-LPA2 Reduces Oxidized Fatty Acids

Purpose Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an emerging cardiovascular risk marker. After low-density lipoprotein (LDL) oxidation, Lp-PLA 2 generates oxidized nonesterified fatty acids and lysophosphatidylcholine, both of which have demonstrated proinflammatory and proapoptotic a...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 2008-02, Vol.22 (1), p.55-58
Main Authors: Rosenson, Robert S., Vracar-Grabar, Marina, Helenowski, Irene
Format: Article
Language:English
Subjects:
1-Alkyl-2-acetylglycerophosphocholine Esterase - antagonists & inhibitors
Adult
Aged
Biological and medical sciences
Cardiology
Cardiovascular system
Dose-Response Relationship, Drug
Fatty Acids, Nonesterified - metabolism
Female
Humans
In Vitro Techniques
Lipid Peroxidation - drug effects
Lipoproteins, LDL - metabolism
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Syndrome - physiopathology
Middle Aged
Oxidation-Reduction
Pharmacology. Drug treatments
Pilot Projects
Citations: Items that this one cites
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Summary:Purpose Lipoprotein associated phospholipase A 2 (Lp-PLA 2 ) is an emerging cardiovascular risk marker. After low-density lipoprotein (LDL) oxidation, Lp-PLA 2 generates oxidized nonesterified fatty acids and lysophosphatidylcholine, both of which have demonstrated proinflammatory and proapoptotic activities. Through the use of a selective inhibitor of Lp-PLA 2 (SB-677116), we investigated whether Lp-PLA 2 participates in the ex vivo generation of oxidized fatty acids (ox-FA). Methods Due to the higher correlation between Lp-PLA 2 activity and small LDL particles, we investigated the effects of a selective Lp-PLA 2 inhibition on production of ox-FA in metabolic syndrome subjects with small LDL size
ISSN:0920-3206
1573-7241
DOI:10.1007/s10557-008-6080-4