Hematological malignancies in chronic inflammatory bowel diseases : report of five cases and review of the literature

Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate, with familiarity and genetic predisposition se...

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Bibliographic Details
Published in:International journal of colorectal disease 2007-05, Vol.22 (5), p.553-558
Main Authors: CRISPINO, Pietro, PICA, Roberta, ANGELUCCI, Erika, CONSOLAZIO, Adriana, RIVERA, Margherita, CASSIERI, Claudio, PAOLUZI, Paolo
Format: Article
Language:English
Subjects:
Adult
Aged
Anemias. Hemoglobinopathies
Asthenia
Azathioprine
Biological and medical sciences
Bowel disease
Cell proliferation
Crohn's disease
Diseases of red blood cells
Familiarity
Female
Fever
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Hematologic and hematopoietic diseases
Hematology
Humans
Immunosuppressive agents
Inflammatory bowel diseases
Inflammatory Bowel Diseases - complications
Intestine
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Leukemia, Myeloid, Acute - complications
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Literature reviews
Lymphoma, B-Cell - complications
Male
Malignancy
Medical sciences
Methotrexate
Middle Aged
Other diseases. Semiology
Patients
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Ulcerative colitis
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Description
Summary:Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate, with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness, and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD (three with ulcerative colitis and two with Crohn's disease) attending our Gastroenterology Unit.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-006-0202-x