Green tea catechin as a chemical chaperone in cancer prevention

Abstract Green tea catechins have recently gained significant acceptance as a cancer preventive, and one of the important features of catechins is their interactions with various target molecules. We recently found a functional and structural similarity between catechins and chaperones: Stochastic c...

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Bibliographic Details
Published in:Cancer letters 2008-03, Vol.261 (1), p.12-20
Main Authors: Kuzuhara, Takashi, Suganuma, Masami, Fujiki, Hirota
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Cancer prevention
Catechin - analogs & derivatives
Catechin - chemistry
Catechin - pharmacology
Chemical chaperone
Conformational analysis
Deoxyribonucleic acid
Disease prevention
DNA
EGCG
Free radicals
Gene expression
Glycerol
Green tea catechin
Hematology, Oncology and Palliative Medicine
Kinases
Lipids
Lung cancer
Molecular Chaperones - chemistry
Neoplasms - prevention & control
Protein Conformation
Proteins
Rodents
Tea
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Summary:Abstract Green tea catechins have recently gained significant acceptance as a cancer preventive, and one of the important features of catechins is their interactions with various target molecules. We recently found a functional and structural similarity between catechins and chaperones: Stochastic conformational analysis in silico revealed numerous conformations of (−)-epigallocatechin gallate, (−)-epicatechin gallate and (−)-epigallocatechin, showing a unique flexibility and mobility of the catechin molecules and suggesting the significance of a galloyl group in conformational variation. Since these conformations result in interaction with various types of molecules, we think that green tea catechin induces cancer preventive activity mediated through a chaperone-like property.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2007.10.037