Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force mi...

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Bibliographic Details
Published in:Nano letters 2008-02, Vol.8 (2), p.420-424
Main Authors: Leroueil, Pascale R, Berry, Stephanie A, Duthie, Kristen, Han, Gang, Rotello, Vincent M, McNerny, Daniel Q, Baker, James R, Orr, Bradford G, Banaszak Holl, Mark M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Cations
Cross-disciplinary physics: materials science
rheology
Crystallization - methods
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Lipid Bilayers - chemistry
Macromolecular Substances - chemistry
Materials science
Materials Testing
Membrane Fluidity
Methods. Procedures. Technologies
Molecular Conformation
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
Others
Particle Size
Physics
Surface Properties
Various methods and equipments
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Summary:Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH2, SiO2-NH2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl0722929