Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation

Supercritical fluid technique have been exploited in extraction, separation and crystallization processes. In the field of pharmaceutics, supercritical carbon dioxide (scCO 2) has been used for the purpose of micronization, polymorphic control, and preparation of solid dispersion and complexes. Part...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2008-02, Vol.60 (3), p.328-338
Main Authors: Moribe, Kunikazu, Tozuka, Yuichi, Yamamoto, Keiji
Format: Article
Language:English
Subjects:
Active pharmaceutical ingredient (API)
Carbon Dioxide - chemistry
Chemistry, Pharmaceutical - methods
Chromatography, Supercritical Fluid - methods
Complex
Crystallization - methods
Drug Delivery Systems - methods
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
Polymorph
Supercritical carbon dioxide
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Summary:Supercritical fluid technique have been exploited in extraction, separation and crystallization processes. In the field of pharmaceutics, supercritical carbon dioxide (scCO 2) has been used for the purpose of micronization, polymorphic control, and preparation of solid dispersion and complexes. Particle design of active pharmaceutical ingredients is important to make the solid dosage forms with suitable physicochemical properties. Control of the characteristic properties of particles, such as size, shape, crystal structure and morphology is required to optimize the formulation. For solubility enhancement of poorly water-soluble drugs, preparation of the solid dispersion or the complexation with proper drugs or excipients should be a promising approach. This review focuses on aspects of polymorphic control and complexation behavior of active pharmaceutical ingredients by scCO 2 processing.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2007.03.023