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Laparoscopic partial nephrectomy in rats

To establish an experimental model of laparoscopic partial nephrectomy (LPN) in rats and to analyze morphological alterations in the renal parenchyma utilizing an electric cautery and harmonic scalpel. Forty Wistar rats were used, divided in 2 experiments with 20 rats each: experiment I, LPN was per...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2007-03, Vol.22 (2), p.152-156
Main Authors: Meyer, Fernando, Ioshii, Sérgio Ossamu, Chin, Eduardo Wei Kin, Esser, Danielle Mussoi, Marcondes, Renata Tomasetti, Patriani, Andressa Hubar, Pimpão, Bruno de Figueiredo
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Language:English
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Summary:To establish an experimental model of laparoscopic partial nephrectomy (LPN) in rats and to analyze morphological alterations in the renal parenchyma utilizing an electric cautery and harmonic scalpel. Forty Wistar rats were used, divided in 2 experiments with 20 rats each: experiment I, LPN was performed with an electric cautery and the rats were subdivided into groups A and B; experiment II, LPN was performed with a harmonic scalpel and they were subdivided into groups C and D. The animals in groups A and C were sacrificed shortly after surgery and the remnant kidney was removed to study the following variables: necroses and degeneration. In groups B and D a laparatomy was performed for retrieval of the remnant kidney on the 14th day after surgery to analyze fibrous scarring. For the variables necroses and fibrous scarring, the electric cautery creates, on average, greater width than that produced by the harmonic scalpel (p=0.0002 and p=0.0068 respectively). Regarding the variable of degeneration, we found no significant difference between the two types of scalpels (p=0.1267). LPN in rats is an adequate and feasible experimental model. The electric cautery caused greater damage to remnant renal tissue when compared to harmonic scalpel.
ISSN:0102-8650
0102-8650
DOI:10.1590/s0102-86502007000200014