Exosomes secreted by bacterially infected macrophages are proinflammatory

Exosomes are small vesicles that are secreted from cells. They are derived from multivesicular endosomes that fuse with the plasma membrane, thereby releasing their internal vesicles into the extracellular environment. Exosomes from antigen-presenting cells contain a range of immunostimulatory molec...

Full description

Saved in:
Bibliographic Details
Published in:Science signaling 2008-02, Vol.1 (6), p.pe8-pe8
Main Authors: O'Neill, Helen C, Quah, Ben J C
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteria - immunology
Bacterial Infections - immunology
Bystander Effect - immunology
Cell Wall - immunology
Dendritic Cells - immunology
Dendritic Cells - microbiology
Dendritic Cells - pathology
Endosomes - immunology
Endosomes - microbiology
Humans
Inflammation Mediators - immunology
Lymphocyte Activation - immunology
Macrophages - immunology
Macrophages - microbiology
Macrophages - pathology
Neutrophils - immunology
Neutrophils - microbiology
Neutrophils - pathology
Secretory Vesicles - immunology
Secretory Vesicles - microbiology
T-Lymphocytes - immunology
T-Lymphocytes - microbiology
T-Lymphocytes - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exosomes are small vesicles that are secreted from cells. They are derived from multivesicular endosomes that fuse with the plasma membrane, thereby releasing their internal vesicles into the extracellular environment. Exosomes from antigen-presenting cells contain a range of immunostimulatory molecules that activate T cells, which suggests that they may have an important role in the propagation of immune responses. Of considerable interest is the finding that exosomes derived from bacterially infected macrophages carry bacterial coat components and use these to stimulate bystander macrophages and neutrophils to secrete proinflammatory mediators, including tumor necrosis factor-alpha, the chemokine regulated upon activation, normal T cell-expressed and -secreted (RANTES, also known as CCL5), and inducible nitric oxide synthase. Here, we address these studies in relation to other findings on dendritic cell-derived exosomes that are also powerful immunoregulators.
ISSN:1945-0877
1937-9145
1937-9145
DOI:10.1126/stke.16pe8