Diastolic dysfunction and autonomic abnormalities in patients with systolic heart failure

Background Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear. Methods and results HRV was measured in 139 patients, aged 64±12 years, 74%...

Full description

Saved in:
Bibliographic Details
Published in:European journal of heart failure 2007-04, Vol.9 (4), p.364-369
Main Authors: Stein, Phyllis K., Tereshchenko, Larisa, Domitrovich, Peter P., Kleiger, Robert E., Perez, Alfonso, Deedwania, Prakash
Format: Article
Language:English
Subjects:
Adult
Aged
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors
Autonomic Nervous System - physiopathology
congestive heart failure
Diastole - drug effects
diastolic dysfunction
Female
Heart Failure - diagnostic imaging
Heart Failure - etiology
Heart Failure - physiopathology
Heart Rate
heart rate variability
Humans
Male
Middle Aged
Pilot Projects
Systole - drug effects
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear. Methods and results HRV was measured in 139 patients, aged 64±12 years, 74% male, LVEF 30±8%. Patients had stable NYHA class II-III CHF on ACE inhibitors or ATII receptor blockers, with LVEF≤40% and BNP≥200 pg/ml. Subjects underwent 2-D echocardiography with Doppler assessment and 24-h Holters. Patients were categorized as having impaired relaxation (E-deceleration time>2 SD above age-adjusted normal values (AANV), E/A≤1, systolic/diastolic pulmonary vein flow≥1; N=30), pseudonormal (E-deceleration time within 2 SD of AANV, E/A=1-2, systolic/diastolic pulmonary vein flow 2 SD below AANV or/and E/A ratio≥2; N=84) Differences were adjusted for clinical covariates using UNIANOVA, p
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2006.09.013