Residual stress ischaemia is associated with blood markers of myocardial structural remodelling

• Published in: European journal of heart failure 2007-04, Vol.9 (4), p.370-376
• Main Authors: Radauceanu, Anca, Moulin, Frédéric, Djaballah, Wassila, Marie, Pierre Y., Alla, François, Dousset, Brigitte, Virion, Jean M., Capiaumont, Josette, Karcher, Gilles, Aliot, Etienne, Zannad, Façez
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Biomarkers; collagen; Collagen Type III - blood; coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Exercise - physiology; exercise ischaemia; Female; fibrosis; Fibrosis - physiopathology; Heart Ventricles - physiopathology; Humans; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Male; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - etiology; Myocardium; Oxidative Stress; remodelling; SPECT; Stroke Volume; Tomography, Emission-Computed, Single-Photon
• ISSN: 1388-9842; 1879-0844
• DOI: 10.1016/j.ejheart.2006.09.010

Background: Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. Aim: To analyze changes in blood markers of fibrosis in patients with chronic CAD exhibiting exercise ischaemia. Methods: Circulating markers of collagen: (i) turnover (amino-terminal propeptide of collagen-III [PIIINP]) and (ii) degradation (matrix metalloproteinase 1 [MMP-1]), were obtained in 139 CAD patients referred for exercise 201Tl-SPECT. Results: In the 57 patients who had SPECT-ischaemia, PIIINP was higher (4.3±2.9 μg L−1 vs. 3.1±1.5 μg L−1, p=0.002) and MMP-1 lower (3.8±2.1 μg L−1 vs. 4.7±2.8 μg L−1, p=0.04) than in the 82 patients without SPECT-ischaemia. PIIINP was independently related to LV volume, SPECT-ischaemia and age, whereas MMP-1 was related to current treatment with ACEI and β-blockers (p