Micronization processes with supercritical fluids: Fundamentals and mechanisms

Supercritical fluid techniques for materials precipitation have been proposed as an alternative to conventional precipitation processes as they allow to improve the performance of these processes in terms of reduction of particle size and control of morphology and particle size distribution, without...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2008-02, Vol.60 (3), p.339-350
Main Authors: Martín, A., Cocero, M.J.
Format: Article
Language:English
Subjects:
Algorithms
Chromatography, Supercritical Fluid - methods
Computer simulation
Drug Delivery Systems - methods
Mathematical modeling
Miniaturization - methods
Models, Theoretical
Particle Size
PGSS
RESS
SAS
Supercritical carbon dioxide
Technology, Pharmaceutical - methods
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Summary:Supercritical fluid techniques for materials precipitation have been proposed as an alternative to conventional precipitation processes as they allow to improve the performance of these processes in terms of reduction of particle size and control of morphology and particle size distribution, without degradation or contamination of the product. These techniques have received much attention during the last years, and their feasibility and performance have been experimentally demonstrated for many substances. One of the main pending tasks is the development of a systematic procedure for the design and scale-up of these processes. This requires not only empirical knowledge, but also information about the fundamentals of the process. This work aims to review the published literature dealing with a fundamental investigation or modeling of supercritical fluid precipitation processes.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2007.06.019