Biopharmaceutical challenges associated with drugs with low aqueous solubility—The potential impact of lipid-based formulations

The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents major challenges for the drug delivery scientists. The role of physicochemical properties in identification of suitable drug candidates for oral lipid-based deliver...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2008-03, Vol.60 (6), p.617-624
Main Authors: O'Driscoll, C.M., Griffin, B.T.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Bioactive excipients
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Drug Carriers - chemistry
Drug Design
Gastrointestinal Tract - metabolism
General pharmacology
Humans
In vitro–in vivo correlations
Lipid-based formulations
Lipids - chemistry
Medical sciences
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Solubility
Water - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents major challenges for the drug delivery scientists. The role of physicochemical properties in identification of suitable drug candidates for oral lipid-based delivery systems is discussed. A knowledge of the interplay of physicochemical and biopharmaceutical drug properties with the physiological environment of the gastro-intestinal tract (GIT), as a prerequisite to successful formulation design, is reviewed. The importance of excipient selection with an emphasis on bioactive excipients is stressed. The need for more examples of in vitro–in vivo correlations as a means of maximizing the development potential and commercial future for lipid-based formulations, and, promoting confidence within the industry for these delivery systems is highlighted.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2007.10.012