Long-term follow-up after neoadjuvant chemotherapy for high-risk cervical cancer during pregnancy

Abstract Background We report on a patient with a high-risk cervical cancer during pregnancy treated with neoadjuvant chemotherapy (NACT) followed by radical surgery. Case A 38-year-old woman was diagnosed with FIGO stage IIA cervical cancer at 19 weeks' gestation. She received four cycles of c...

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Bibliographic Details
Published in:Gynecologic oncology 2007-04, Vol.105 (1), p.269-272
Main Authors: Bader, Arnim A, Petru, Edgar, Winter, Raimund
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Cervical cancer
Cesarean Section
Cisplatin - administration & dosage
Female
Hematology, Oncology and Palliative Medicine
Humans
Hysterectomy
Lymph Node Excision
Neoadjuvant chemotherapy
Neoadjuvant Therapy
Neoplasm Staging
Obstetrics and Gynecology
Pregnancy
Pregnancy Complications, Neoplastic - drug therapy
Pregnancy Complications, Neoplastic - pathology
Pregnancy Complications, Neoplastic - surgery
Risk Factors
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
Vincristine - administration & dosage
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Summary:Abstract Background We report on a patient with a high-risk cervical cancer during pregnancy treated with neoadjuvant chemotherapy (NACT) followed by radical surgery. Case A 38-year-old woman was diagnosed with FIGO stage IIA cervical cancer at 19 weeks' gestation. She received four cycles of cisplatin (50 mg/m2 ) and vincristine (1 mg/m2 ) at 3-week intervals starting at 23 weeks' gestation. A cesarean section with radical hysterectomy and pelvic lymphadenectomy was performed at 33 weeks, delivering a 1920 g male newborn. Histology showed a poorly differentiated squamous cell carcinoma with lymph vascular invasion and pelvic lymph node metastases. The patient received three further cycles of chemotherapy. Both mother and child are healthy at 80 months after the primary diagnosis. Conclusion NACT followed by radical surgery may be effective in selected patients with invasive cervical cancer during pregnancy.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2007.01.009