What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression

Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic anima...

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Bibliographic Details
Published in:Behavioural brain research 2007-04, Vol.179 (1), p.1-18
Main Authors: KALUEFF, A. V, WHEATON, M, MURPHY, D. L
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Anxiety - etiology
Anxiety disorders. Neuroses
Behavioral psychophysiology
Behavioral Research - methods
Biological and medical sciences
Depression
Depression - etiology
Depressive Disorder - etiology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Medical sciences
Mental Disorders - etiology
Mice
Mice, Transgenic
Mood disorders
Obsessive-compulsive disorders
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Stress, Psychological - complications
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Summary:Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2007.01.023