H-reflex and motor nerve conduction studies in growth retarded newborn babies

• Published in: Neuroscience letters 2008-02, Vol.432 (3), p.188-192
• Main Authors: Dereddy, Narendra Reddy, Muthusami, Sunil, Bhatia, B.D., Prakash, Udai
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Electric Stimulation; Female; Fetal Growth Retardation - physiopathology; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; H-reflex; H-Reflex - physiology; Humans; Infant; Infant, Newborn; Intrauterine growth retardation; Male; Motor nerve conduction velocity; Neural Conduction - physiology; Neuronal excitability; Newborn; Reaction Time - physiology; Reaction Time - radiation effects; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2007.12.018

Objective To demonstrate the accelerated postnatal maturation/myelination in growth retarded babies compensating the deficit suffered by them during intrauterine life. Methods We studied 16 babies within the first 3 days of birth. These included 6 full term appropriate for gestational age babies (FT AGA) and 10 full term intrauterine growth retarded (FT IUGR). A separate group of 16 babies was examined at 2 months of age. In this group 7 were FT AGA and 9 were FT IUGR at the time of birth. H-reflex latency (HRL), motor nerve conduction velocity (MNCV) and H-reflex excitability (H/M) were measured in the right lower limb. Anthropometric measurements of the babies were also recorded meticulously. All the babies were neurologically normal on clinical evaluation. Result At birth, MNCV was significantly lower in FT IUGR babies compared to FT AGA babies. However at the age of 2 months the MNCV of both FT AGA and FT IUGR was comparable. Other parameters (HRL and H/M) in the IUGR babies were comparable with normal babies both at birth and 2 months of age. In FT IUGR babies crown heel length and weight was significantly lower than FT AGA babies both at the time of birth and at 2 months of age. Conclusion and significance The findings suggest that FT IUGR babies demonstrate accelerated postnatal peripheral neural maturation. At 2 months of age, the motor nerve conduction velocity of these growth retarded babies were comparable to that observed in normal AGA babies of similar age. This provides an insight into the functional aspect of the proven theories of decreased peripheral myelination in FT IUGR babies with subsequent rapid postnatal myelination that renders these babies neurologically equivalent to FT AGA babies despite not achieving comparable anthropometric parameters.