The effect of short-term exercise on plasma leptin levels in patients with anorexia nervosa

Abstract Plasma leptin concentrations are markedly reduced in malnourished patients with anorexia nervosa (AN). Whether the long-term underweight and low-fat stores affect the leptin response to exercise remains unknown. We investigated the effect of 45-minute cycle ergometer exercise (2 W kg−1 of l...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2007-04, Vol.56 (4), p.497-503
Main Authors: Dostalova, Ivana, Bartak, Vladimir, Papezova, Hana, Nedvidkova, Jara
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anorexia nervosa
Anorexia Nervosa - blood
Anorexia Nervosa - physiopathology
Biological and medical sciences
Body Weight
Eating behavior disorders
Endocrinology & Metabolism
Exercise
Glycerol - blood
Humans
Insulin - blood
Leptin - blood
Medical sciences
Metabolic diseases
Norepinephrine - blood
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radioimmunoassay
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Summary:Abstract Plasma leptin concentrations are markedly reduced in malnourished patients with anorexia nervosa (AN). Whether the long-term underweight and low-fat stores affect the leptin response to exercise remains unknown. We investigated the effect of 45-minute cycle ergometer exercise (2 W kg−1 of lean body mass [LBM]) on plasma leptin, norepinephrine (NE), glycerol, and insulin levels in 10 patients with AN and in 15 healthy age-matched women (C). Plasma leptin levels immediately and 90 minutes after the exercise bout were significantly reduced compared with basal leptin levels in both AN and C groups ( P < .05). Compared with the control trial, leptin levels were significantly lower immediately and 90 minutes after exercise in the AN group ( P < .05) but not in the C group. Basal and exercise-induced plasma glycerol and NE levels did not differ significantly between the groups. Basal and exercise-induced plasma insulin levels were significantly lower in the AN group compared with the C group ( P < .05). In conclusion, we demonstrated that a single bout of low-intensity exercise significantly reduces plasma leptin levels in patients with AN. In healthy women, exercise had no effect on lowering leptin concentrations beyond the diurnal decrease that occurs in the absence of exercise. Neither NE nor insulin are responsible for the different response of leptin to exercise in AN.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2006.11.008