Intravenous anti‐D immunoglobulin in the treatment of resistant immune thrombocytopenic purpura in pregnancy

A 35‐week pregnant 38‐year‐old woman presented with isolated thrombocytopenia (platelet count 4 × 109/l). Investigations confirmed immune thrombocytopenic purpura, and she received treatment with prednisolone and intravenous immunoglobulins with no increment in the platelet count. At 37 and 38 weeks...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2007-04, Vol.114 (4), p.505-507
Main Authors: Sieunarine, K, Shapiro, S, Al Obaidi, MJ, Girling, J
Format: Article
Language:English
Subjects:
Adult
Anti‐D
Biological and medical sciences
Drug Resistance
Female
Glucocorticoids - therapeutic use
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
immune thrombocytopenia
Immunoglobulins, Intravenous - administration & dosage
Medical sciences
Platelet diseases and coagulopathies
Prednisolone - therapeutic use
Pregnancy
Purpura, Thrombocytopenic - therapy
Rho(D) Immune Globulin - administration & dosage
WinRho
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Summary:A 35‐week pregnant 38‐year‐old woman presented with isolated thrombocytopenia (platelet count 4 × 109/l). Investigations confirmed immune thrombocytopenic purpura, and she received treatment with prednisolone and intravenous immunoglobulins with no increment in the platelet count. At 37 and 38 weeks of the pregnancy, she received two doses of WinRho (anti‐D immunoglobulin) at 50 μg/kg. Five days later, with a platelet count of 46 × 109/l, she had an uncomplicated normal vaginal delivery. WinRho is a useful adjunct to other first‐line treatment modalities for immune thrombocytopenia in pregnancy.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2007.01234.x