Intracranial volume measurement of sagittal craniosynostosis

Abstract We report 41 cases of non-syndromic isolated sagittal synostosis in which evaluation of intracranial volumes was undertaken. Twenty-six were male and fifteen were female. The measured intracranial volumes were then compared with normal age-corrected values. We have found that intracranial v...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2007-05, Vol.14 (5), p.455-458
Main Authors: Anderson, Peter J, Netherway, David J, McGlaughlin, Karen, David, David J
Format: Article
Language:English
Subjects:
Cephalometry - methods
Cephalometry - statistics & numerical data
Craniosynostoses - genetics
Craniosynostoses - pathology
Craniosynostosis
Female
Humans
Imaging, Three-Dimensional
Infant
Male
Neurology
Receptor, Fibroblast Growth Factor, Type 3 - genetics
Reference Values
Sagittal suture
Sex Characteristics
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Summary:Abstract We report 41 cases of non-syndromic isolated sagittal synostosis in which evaluation of intracranial volumes was undertaken. Twenty-six were male and fifteen were female. The measured intracranial volumes were then compared with normal age-corrected values. We have found that intracranial volumes were significantly larger than the normal population intracranial volumes in both sexes. However the statistical significance of this finding was much greater in females, ( p < 0.00002), than males ( p < 0.040), which was only of borderline significance. The results confirm smaller, earlier studies that intracranial volumes in sagittal synostosis patients are larger than average for age-corrected normal values. Analysis of a sub-set of six patients with sagittal synostosis who were found to have a common polymorphism 294C > T (Asn294Asn) in FGFR3 (fibroblast growth factor Receptor 3) on genetic testing were compared to age and sex matched cases of non-syndromic sagittal synostosis (without an underlying mutation) which confirmed that there were no discernable differences in intracranial volumes between the two groups. We conclude that this investigation supports the role of cranial re-shaping to improve cosmesis as the primary aim of surgical correction in this condition, in the absence of raised intracranial pressure.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2006.07.001