A Case Report of the Therapeutic Effect of Cryofiltration in a Patient With Glucocorticoid‐Resistant Ulcerative Colitis

:  Ulcerative colitis (UC) is characterized by chronic inflammation of the colon and its cause and pathogenesis have not been fully clarified. Although UC is treated with various drugs, including 5‐amino‐salycilate and glucocorticoids, some patients are resistant to them. It was recently reported th...

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Published in:Therapeutic apheresis and dialysis 2007-04, Vol.11 (2), p.159-162
Main Authors: Ohkawara, Tatsuya, Saito, Masao, Nakagawa, Souichi, Ohizumi, Hiroko, Tamaki, Toru, Yonekawa, Motoki, Takeda, Hiroshi, Asaka, Masahiro, Nishihira, Jun, Kawamura, Akio
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Antigen-Antibody Complex - blood
Colitis, Ulcerative - blood
Colitis, Ulcerative - immunology
Colitis, Ulcerative - therapy
Cryofiltration
Cryotherapy
Drug Resistance
Female
Filtration
Humans
Immunoglobulins - blood
Interleukin-10 - blood
Interleukin‐10
Treatment Outcome
Ulcerative colitis
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Summary::  Ulcerative colitis (UC) is characterized by chronic inflammation of the colon and its cause and pathogenesis have not been fully clarified. Although UC is treated with various drugs, including 5‐amino‐salycilate and glucocorticoids, some patients are resistant to them. It was recently reported that apheresis, such as leukocytapheresis and granulocytapheresis, improves intestinal inflammation in refractory cases of UC. On the other hand, cryofiltration, in which plasma apheresis is used to remove immunoglobulin and immune complexes, has been used for the treatment of autoimmune diseases. We herein report a case of glucocorticoid‐resistant UC successfully treated with cryofiltration. Interestingly, the level of interleukin‐10 (IL‐10) in the patient's serum was markedly increased after eight sessions of cryofiltration. This suggests that cryofiltration suppresses intestinal inflammation, in part via up‐regulation of IL‐10.
ISSN:1744-9979
1744-9987
DOI:10.1111/j.1744-9987.2007.00418.x