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Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease
The circulating form of endothelial progenitors cells (EPCs) are derivated from bone marrow (BM)‐derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (C...
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| Published in: | European journal of haematology 2008-03, Vol.80 (3), p.258-264 |
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| Main Authors: | , , , , , , , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4057-3944ca5783fcdfaced00f509d87c96045340a18516b5387dee6bdb02e9be7193 |
| container_end_page | 264 |
| container_issue | 3 |
| container_start_page | 258 |
| container_title | European journal of haematology |
| container_volume | 80 |
| creator | Liguori, Antonio Fiorito, Carmela Balestrieri, Maria Luisa Crimi, Ettore Bruzzese, Giuseppe Williams-Ignarro, Sharon D'Amora, Maurizio Sommese, Linda Grimaldi, Vincenzo Minucci, Pellegrino Biagio Giovane, Alfonso Farzati, Bartolomeo Ignarro, Louis J. Napoli, Claudio |
| description | The circulating form of endothelial progenitors cells (EPCs) are derivated from bone marrow (BM)‐derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony‐forming unit (CFU) capacity of BM‐derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P |
| doi_str_mv | 10.1111/j.1600-0609.2007.01007.x |
| format | article |
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Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony‐forming unit (CFU) capacity of BM‐derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 ± 21.2 vs. 75.4 ± 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/j.1600-0609.2007.01007.x</identifier><identifier>PMID: 18081701</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Bone Marrow Cells - pathology ; Cell Movement - physiology ; Cells, Cultured ; Colony-Forming Units Assay ; Coronary Disease - blood ; Coronary Disease - pathology ; coronary heart disease ; Endothelium, Vascular - pathology ; Hematopoietic Stem Cells - pathology ; Humans ; Leukocytes, Mononuclear - pathology ; Male ; Middle Aged ; progenitor cells ; stem cells ; Vascular Endothelial Growth Factor A - physiology</subject><ispartof>European journal of haematology, 2008-03, Vol.80 (3), p.258-264</ispartof><rights>2007 The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4057-3944ca5783fcdfaced00f509d87c96045340a18516b5387dee6bdb02e9be7193</citedby><cites>FETCH-LOGICAL-c4057-3944ca5783fcdfaced00f509d87c96045340a18516b5387dee6bdb02e9be7193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18081701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liguori, Antonio</creatorcontrib><creatorcontrib>Fiorito, Carmela</creatorcontrib><creatorcontrib>Balestrieri, Maria Luisa</creatorcontrib><creatorcontrib>Crimi, Ettore</creatorcontrib><creatorcontrib>Bruzzese, Giuseppe</creatorcontrib><creatorcontrib>Williams-Ignarro, Sharon</creatorcontrib><creatorcontrib>D'Amora, Maurizio</creatorcontrib><creatorcontrib>Sommese, Linda</creatorcontrib><creatorcontrib>Grimaldi, Vincenzo</creatorcontrib><creatorcontrib>Minucci, Pellegrino Biagio</creatorcontrib><creatorcontrib>Giovane, Alfonso</creatorcontrib><creatorcontrib>Farzati, Bartolomeo</creatorcontrib><creatorcontrib>Ignarro, Louis J.</creatorcontrib><creatorcontrib>Napoli, Claudio</creatorcontrib><title>Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>The circulating form of endothelial progenitors cells (EPCs) are derivated from bone marrow (BM)‐derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony‐forming unit (CFU) capacity of BM‐derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 ± 21.2 vs. 75.4 ± 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Marrow Cells - pathology</subject><subject>Cell Movement - physiology</subject><subject>Cells, Cultured</subject><subject>Colony-Forming Units Assay</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - pathology</subject><subject>coronary heart disease</subject><subject>Endothelium, Vascular - pathology</subject><subject>Hematopoietic Stem Cells - pathology</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>progenitor cells</subject><subject>stem cells</subject><subject>Vascular Endothelial Growth Factor A - physiology</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkMFu3CAURVHVqpmm-YWKVXeePmwMZtFFFWWStFEjVZEqdYMwfm6Y2sYFRpn8fXBmlG7LApC45_J0CKEM1iyvT9s1EwAFCFDrEkCugS37_hVZvTy8JitQUBacc3ZC3sW4BYBSMfmWnLAGGiaBrYje7CabnJ_MQN04GxdGnBL1Pb3H0SQ_e4fJWToH_xsnl3ygFochUjfR2SSXw5E-uHRPrQ-5JTxm0IREOxfRRHxP3vRmiHh2PE_J3ebi7vyquLm9vD7_clNYDrUsKsW5NbVsqt52vbHYAfQ1qK6RVgngdcXBsKZmoq2rRnaIou1aKFG1KJmqTsnHQ22e8-8OY9Kji8ugZkK_i1pCxQQXZQ42h6ANPsaAvZ6DG_PYmoFe3OqtXhTqRaFe3Opnt3qf0Q_HP3btiN0_8CgzBz4fAg9uwMf_LtYXX6-WW-aLA-9iwv0Lb8IfLWQla_3z-6X-9U1sFNSl_lE9Acl8mDo</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Liguori, Antonio</creator><creator>Fiorito, Carmela</creator><creator>Balestrieri, Maria Luisa</creator><creator>Crimi, Ettore</creator><creator>Bruzzese, Giuseppe</creator><creator>Williams-Ignarro, Sharon</creator><creator>D'Amora, Maurizio</creator><creator>Sommese, Linda</creator><creator>Grimaldi, Vincenzo</creator><creator>Minucci, Pellegrino Biagio</creator><creator>Giovane, Alfonso</creator><creator>Farzati, Bartolomeo</creator><creator>Ignarro, Louis J.</creator><creator>Napoli, Claudio</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease</title><author>Liguori, Antonio ; Fiorito, Carmela ; Balestrieri, Maria Luisa ; Crimi, Ettore ; Bruzzese, Giuseppe ; Williams-Ignarro, Sharon ; D'Amora, Maurizio ; Sommese, Linda ; Grimaldi, Vincenzo ; Minucci, Pellegrino Biagio ; Giovane, Alfonso ; Farzati, Bartolomeo ; Ignarro, Louis J. ; Napoli, Claudio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4057-3944ca5783fcdfaced00f509d87c96045340a18516b5387dee6bdb02e9be7193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Marrow Cells - pathology</topic><topic>Cell Movement - physiology</topic><topic>Cells, Cultured</topic><topic>Colony-Forming Units Assay</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - pathology</topic><topic>coronary heart disease</topic><topic>Endothelium, Vascular - pathology</topic><topic>Hematopoietic Stem Cells - pathology</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>progenitor cells</topic><topic>stem cells</topic><topic>Vascular Endothelial Growth Factor A - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liguori, Antonio</creatorcontrib><creatorcontrib>Fiorito, Carmela</creatorcontrib><creatorcontrib>Balestrieri, Maria Luisa</creatorcontrib><creatorcontrib>Crimi, Ettore</creatorcontrib><creatorcontrib>Bruzzese, Giuseppe</creatorcontrib><creatorcontrib>Williams-Ignarro, Sharon</creatorcontrib><creatorcontrib>D'Amora, Maurizio</creatorcontrib><creatorcontrib>Sommese, Linda</creatorcontrib><creatorcontrib>Grimaldi, Vincenzo</creatorcontrib><creatorcontrib>Minucci, Pellegrino Biagio</creatorcontrib><creatorcontrib>Giovane, Alfonso</creatorcontrib><creatorcontrib>Farzati, Bartolomeo</creatorcontrib><creatorcontrib>Ignarro, Louis J.</creatorcontrib><creatorcontrib>Napoli, Claudio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liguori, Antonio</au><au>Fiorito, Carmela</au><au>Balestrieri, Maria Luisa</au><au>Crimi, Ettore</au><au>Bruzzese, Giuseppe</au><au>Williams-Ignarro, Sharon</au><au>D'Amora, Maurizio</au><au>Sommese, Linda</au><au>Grimaldi, Vincenzo</au><au>Minucci, Pellegrino Biagio</au><au>Giovane, Alfonso</au><au>Farzati, Bartolomeo</au><au>Ignarro, Louis J.</au><au>Napoli, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2008-03</date><risdate>2008</risdate><volume>80</volume><issue>3</issue><spage>258</spage><epage>264</epage><pages>258-264</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>The circulating form of endothelial progenitors cells (EPCs) are derivated from bone marrow (BM)‐derived hematopoietic stem cells (HSCs). Enhanced mobilization of EPCs was shown to be linked to cardiac diseases. This study investigated whether reduced EPC levels in advanced coronary heart disease (CHD) are secondary to a functional exhaustion of HSCs in the BM or to reduced mobilization. Number and functional properties of EPCs were assessed in 15 healthy controls, and 40 patients with CHD. The colony‐forming unit (CFU) capacity of BM‐derived mononuclear cells and the CD34+ HSC number were examined in four healthy volunteers, and 15 CHD patients. EPC number was reduced in CHD patients (P < 0.01 vs. controls). Moreover, the migratory capacity was significantly impaired in EPCs of CHD patients (P < 0.05 vs. controls). On multivariate analysis, CHD was an independent predictor of functional EPC impairment. CFUs were reduced in CHD patients (59.6 ± 21.2 vs. 75.4 ± 25.8 in controls, P < 0.05). CHD was also predictor of impaired CFU capacity. In this small clinical study, CHD is associated with selective impairment of HSC function in the BM and in the peripheral blood, which may contribute to impairment of cardiac function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18081701</pmid><doi>10.1111/j.1600-0609.2007.01007.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | European journal of haematology, 2008-03, Vol.80 (3), p.258-264 |
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| language | eng |
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| source | Wiley |
| subjects | Aged Aged, 80 and over Bone Marrow Cells - pathology Cell Movement - physiology Cells, Cultured Colony-Forming Units Assay Coronary Disease - blood Coronary Disease - pathology coronary heart disease Endothelium, Vascular - pathology Hematopoietic Stem Cells - pathology Humans Leukocytes, Mononuclear - pathology Male Middle Aged progenitor cells stem cells Vascular Endothelial Growth Factor A - physiology |
| title | Functional impairment of hematopoietic progenitor cells in patients with coronary heart disease |
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