DNA-Controlled Reversible Switching of Peptide Conformation and Bioactivity

A DNA switch: Hybridization with DNA controls the conformation of a peptide nucleic acid (PNA)–peptide conjugate. This reversible process can activate (see scheme) or deactivate the binding propensity of the peptide for a protein target involved in cellular signal transduction.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (15), p.2704-2707
Main Authors: Röglin, Lars, Ahmadian, Mohammad R., Seitz, Oliver
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
DNA
DNA - chemistry
DNA - metabolism
fluorescence polarization
Fluorescence Polarization - methods
hybridization
Molecular Sequence Data
Nucleic Acid Conformation
Nucleic Acid Hybridization
nucleic acids
peptides
Peptides - chemistry
Peptides - pharmacology
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Description
Summary:A DNA switch: Hybridization with DNA controls the conformation of a peptide nucleic acid (PNA)–peptide conjugate. This reversible process can activate (see scheme) or deactivate the binding propensity of the peptide for a protein target involved in cellular signal transduction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603889