Radioprotective Effect of Lyophyllum Decastes and the Effect on Immunological Functions in Irradiated Mice

• Published in: Journal of traditional Chinese medicine 2007-03, Vol.27 (1), p.70-75
• Main Authors: Nakamura, Takashi, Itokawa, Yuka, Tajima, Masayuki, Ukawa, Yuuichi, Cho, Kwang-Ho, Choi, Jung-Sook, Ishid, Torao, Gu, Yeunhwa
• Format: Article
• Language: English
• Subjects: Administration, Oral; Agaricales - chemistry; Animals; Blood Cell Count; Blood Cells - radiation effects; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Neoplasms - immunology; Neoplasms - radiotherapy; Radiation-Protective Agents - administration & dosage; Radiation-Protective Agents - chemistry; Random Allocation; X-Rays; 免疫机能; 受辐照小白鼠; 担子菌提取物; 荷叶离褶伞; 辐射防护作用
• ISSN: 0255-2922

In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing （LDS）, a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells （lymphocytes, monocyte, and granulocytes） one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of ieukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary irffections associated with irradiation.