Influence of route of gastric transposition on oxygen supply at cervical oesophagogastric anastomoses

Background: The microcirculation and oxygen supply at the oesophagogastric anastomosis are crucial factors that influence anastomotic healing after oesophagectomy. Methods: Twenty‐nine patients (mean age 61·7 years) underwent gastric transposition via an orthotopic (14) or retrosternal (15) route. I...

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Bibliographic Details
Published in:British journal of surgery 2008-03, Vol.95 (3), p.344-349
Main Authors: Anegg, U., Lindenmann, J., Maier, A., Smolle, J., Smolle-Jüttner, F. M.
Format: Article
Language:English
Subjects:
Aged
Anastomosis, Surgical
Biological and medical sciences
Esophageal Diseases - blood
Esophageal Diseases - surgery
Esophagectomy - methods
Female
Gastrectomy - methods
General aspects
Humans
Intraoperative Care
Ligation
Male
Medical sciences
Middle Aged
Oxygen - blood
Partial Pressure
Postoperative Complications - etiology
Stomach - blood supply
Stomach - transplantation
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Summary:Background: The microcirculation and oxygen supply at the oesophagogastric anastomosis are crucial factors that influence anastomotic healing after oesophagectomy. Methods: Twenty‐nine patients (mean age 61·7 years) underwent gastric transposition via an orthotopic (14) or retrosternal (15) route. Interstitial partial pressure of oxygen (PO2) of the stomach in the anastomotic region was measured during oesophagectomy and in the intensive care unit. Interstitial PO2 values were determined after ligation of the short gastric vessels, after ligation of the left gastric artery, after forming the conduit and after gastric transposition. Postoperative measurements were recorded during endotracheal intubation, while breathing oxygen by mask or through the nose, and while breathing air. Results: Interstitial PO2 levels were significantly higher before ligation of the left gastric artery than after ligation (mean 76·1 (95 per cent confidence interval 54·9 to 103·1) versus 44·9 (24·6 to 77·1) mmHg; P = 0·001). Levels were also higher following orthotopic transposition compared with the retrosternal route (68·2 (44·0 to 118·8) versus 24·6 (10·7 to 39·4) mmHg; P = 0·001) and during each postoperative measurement period. No differences were found between the various oxygen supply systems. Conclusion: Oxygen supply at the anastomosis of the gastric conduit reaches higher levels after orthotopic than retrosternal gastric transposition. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Orthotopic route is preferable
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5997