The Invention and Development of Enflurane, Isoflurane, Sevoflurane, and Desflurane

Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at l...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 2008-03, Vol.108 (3), p.531-533
Main Author: TERRELL, Ross C
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Chemistry, Pharmaceutical - trends
Drug Design
Enflurane - chemical synthesis
Humans
Hydrocarbons, Fluorinated - chemical synthesis
Isoflurane - analogs & derivatives
Isoflurane - chemical synthesis
Medical sciences
Methyl Ethers - chemical synthesis
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Summary:Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.
ISSN:0003-3022
1528-1175
DOI:10.1097/aln.0b013e31816499cc