Mass spectrometric detection of and similarities between 1-androgens

Regularly new anabolic steroids appear on the black market. In most cases these substances are marketed on websites or are confiscated during inspections. 1,(5α)-Androstene-17β-ol-3-one, also known as 1-testosterone, is one of these substances presented to body-builders as a nutritional supplement o...

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Bibliographic Details
Published in:Analytica chimica acta 2007-03, Vol.586 (1-2), p.57-72
Main Authors: Verheyden, K., Le Bizec, B., Courtheyn, D., Mortier, V., Vandewiele, M., Gillis, W., Vanthemsche, P., De Brabander, H.F., Noppe, H.
Format: Article
Language:English
Subjects:
1-Androstenediol
1-Testosterone
Administration, Oral
Anabolic Agents - analysis
Analytical chemistry
Androgens - analysis
Androstenediol - analysis
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, Gas - methods
Chromatography, High Pressure Liquid - methods
Chromatography, Liquid - methods
Doping in Sports
Exact sciences and technology
Gas chromatographic methods
Gas Chromatography-Mass Spectrometry
Mass Spectrometry - methods
Models, Chemical
Multiple mass spectrometry
Other chromatographic methods
Spectrometric and optical methods
Steroids - analysis
Substance Abuse Detection - methods
Testosterone - analogs & derivatives
Testosterone - analysis
Testosterone - chemistry
Weight Lifting
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Summary:Regularly new anabolic steroids appear on the black market. In most cases these substances are marketed on websites or are confiscated during inspections. 1,(5α)-Androstene-17β-ol-3-one, also known as 1-testosterone, is one of these substances presented to body-builders as a nutritional supplement or a pro-hormone. 1-Testosterone closely resembles the natural hormone testosterone except for a 1,2-double bound instead of a 4,5-double bound. 1-Androstene-3β,17β-diol is transformed into 1-testosterone after oral administration. 1-Testosterone, 1-androstene-3β,17β-diol and some other related ‘new’ anabolic steroids were studied with gas chromatography coupled to mass spectrometry (GC–MS) and Liquid chromatography coupled to tandem mass spectrometry (LC–MS2) methods. Similarities in spectra to known analytes, which may lead to pitfalls in the interpretation of the derivatised analytes, are discussed.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2006.10.058