Brugada syndrome unmasked by lithium treatment

The Brugada syndrome is a rare genetic disease that can lead to death. Its diagnosis requires electrocardiography. A 36-year-old man was admitted with syncope. Brugada syndrome was diagnosed by the typical ECG pattern. The interaction between lithium therapy and ECG was shown clearly by the alternat...

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Bibliographic Details
Published in:La Presse médicale (1983) 2007-04, Vol.36 (4 Pt 1), p.612-614
Main Authors: Sandras, Raphael, Lesaffre, Francois, Lacotte, Jérome, Nazeyrollas, Pierre
Format: Article
Language:fre
Subjects:
Adult
Bipolar Disorder - drug therapy
Brugada Syndrome - diagnosis
Electrocardiography
Humans
Lithium Compounds - therapeutic use
Male
Psychotropic Drugs - therapeutic use
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Summary:The Brugada syndrome is a rare genetic disease that can lead to death. Its diagnosis requires electrocardiography. A 36-year-old man was admitted with syncope. Brugada syndrome was diagnosed by the typical ECG pattern. The interaction between lithium therapy and ECG was shown clearly by the alternating type 1 and type 3 Brugada ECG patterns, depending on lithium status. The Brugada syndrome may be unmasked by lithium therapy, due to its properties as a Na+ channel blocker, even at low doses. This case also demonstrated the usefulness of ECG in detecting the Brugada syndrome before and during lithium prescription.
ISSN:0755-4982