Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells

Sialic acids are structurally diverse molecules that have important roles in the physiological reactions and characteristics of prokaryotes and eukaryotes. These include the ability to mask epitopes on underlying glycan chains and to repulse negatively charged moieties. Here, we describe the metabol...

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Bibliographic Details
Published in:Drug discovery today 2007-04, Vol.12 (7), p.319-326
Main Authors: Byrne, Barry, Donohoe, Gerard G., O’Kennedy, Richard
Format: Article
Language:English
Subjects:
Animals
Drug Design
Drug Industry - methods
Drug Industry - trends
Eukaryotic Cells - metabolism
Glycoproteins - chemistry
Glycoproteins - therapeutic use
Humans
Molecular Structure
Pharmaceutical Preparations - chemistry
Prokaryotic Cells - metabolism
Sialic Acids - chemistry
Sialic Acids - immunology
Sialic Acids - metabolism
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Summary:Sialic acids are structurally diverse molecules that have important roles in the physiological reactions and characteristics of prokaryotes and eukaryotes. These include the ability to mask epitopes on underlying glycan chains and to repulse negatively charged moieties. Here, we describe the metabolism and immunological relevance of sialic acids and outline how their properties have been exploited by the pharmaceutical industry to enhance the therapeutic properties of proteins such as asparaginase and darbepoetin α.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2007.02.010