Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder

Evidence has supported a role for serotonin system dysfunction in the pathogenesis of the obsessive–compulsive disorder (OCD). Many studies examined the association between OCD and a functional polymorphism of the serotonin transporter gene promoter (5-HTTLPR) but yielded inconsistent results. Curre...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2007-04, Vol.31 (3), p.683-689
Main Author: Lin, Pao-Yen
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Association study
Biological and medical sciences
Confidence Intervals
Databases, Factual - statistics & numerical data
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Medical sciences
MEDLINE - statistics & numerical data
Meta-analysis
Meta-Analysis as Topic
Neuropharmacology
Obsessive-Compulsive Disorder - genetics
Obsessive-compulsive disorders
Obsessive–compulsive disorder
Odds Ratio
Pharmacology. Drug treatments
Polymorphism
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Retrospective Studies
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin transporter
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Summary:Evidence has supported a role for serotonin system dysfunction in the pathogenesis of the obsessive–compulsive disorder (OCD). Many studies examined the association between OCD and a functional polymorphism of the serotonin transporter gene promoter (5-HTTLPR) but yielded inconsistent results. Current study aimed to determine conclusively whether there is an association by using a meta-analytic method. Over 3000 subjects from 13 independent case-control association studies were included in the analysis. By using random effects model, data from these studies were pooled to compare the genotypes and allelic distribution of the 5-HTTLPR polymorphism between OCD patients and control subjects. In the analysis, OCD was found to be associated with the SS homozygous genotype (OR = 1.21, p = 0.04), but was inversely associated with the LS heterozygous genotype (OR = 0.79, p = 0.03). No association with the LL homozygous genotype or the allelic distribution was found. These results suggest that variations of the serotonin transporter gene influence the risk of OCD, but their functional roles in the pathogenesis of OCD need to be elucidated.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2006.12.024