Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident—With focus on immunoglobulin heavy chain gene analysis

Abstract Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients. Clean-up workers of the second quarter of 1986 ( n = 19) were picked out as separ...

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Bibliographic Details
Published in:Leukemia research 2008-04, Vol.32 (4), p.535-545
Main Authors: Abramenko, Iryna, Bilous, Nadia, Chumak, Anatoliy, Davidova, Ekaterina, Kryachok, Iryna, Martina, Zoya, Nechaev, Stanislav, Dyagil, Iryna, Bazyka, Dmytriy, Bebeshko, Vladimir
Format: Article
Language:English
Subjects:
Adult
Aged
Chernobyl Nuclear Accident
Chronic lymphocytic leukemia
Cohort Studies
Female
Gene Expression
Gene Rearrangement
Hematology, Oncology and Palliative Medicine
Humans
Immunoglobulin Heavy Chains - genetics
Immunoglobulin variable heavy chain (IgVH) gene usage
Immunoglobulin Variable Region - genetics
Ionizing radiation
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Male
Middle Aged
Neoplasms, Second Primary - genetics
Polymerase Chain Reaction
Radiation, Ionizing
Survival Rate
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Summary:Abstract Clinical data and immunoglobulin variable heavy chain (IgVH) gene configuration were analyzed in 47 CLL patients, exposed to ionizing radiation (IR) due to Chernobyl NPP accident, and 141 non-exposed patients. Clean-up workers of the second quarter of 1986 ( n = 19) were picked out as separate group with the highest number of unmutated cases (94.4%), increased usage of IgVH1-69 (33.3%) and IgVH3-21 (16.7%) genes, high frequency of secondary solid tumors (6 cases) and Richter transformation (4 cases). These preliminary data suggest that CLL in the most suffered contingent due to Chernobyl NPP accident might have some specific features.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2007.08.013