Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia

The association of the tumor necrosis factor alpha (TNFα) −G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFα cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of gene...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.318-324
Main Authors: Morar, B., Schwab, S.G., Albus, M., Maier, W., Lerer, B., Wildenauer, D.B.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
behavioral genetics
Biological and medical sciences
complex disorders
cytokines
Family
Gene Frequency
General aspects
Genes, MHC Class I
Genetic Markers
Haplotypes
Humans
Linkage Disequilibrium
major histocompatibility complex
Medical genetics
Medical sciences
mental disorders
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
Tumor Necrosis Factor-alpha - genetics
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Summary:The association of the tumor necrosis factor alpha (TNFα) −G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFα cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFα gene is located as well as association with the −G308A promoter polymorphism. While the common G‐allele shows association in our sample, association with the A‐allele has been reported by other groups. This suggests linkage disequilibrium (LD) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165‐kb region around this polymorphism. We detected nominally significant associations (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30451