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Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia
The association of the tumor necrosis factor alpha (TNFα) −G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFα cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of gene...
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| Published in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.318-324 |
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| cites | cdi_FETCH-LOGICAL-c4321-ab6741f6d66e657c9221304f70ab3def356e4b7dedb235350d38cf2b882717313 |
| container_end_page | 324 |
| container_issue | 3 |
| container_start_page | 318 |
| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 144B |
| creator | Morar, B. Schwab, S.G. Albus, M. Maier, W. Lerer, B. Wildenauer, D.B. |
| description | The association of the tumor necrosis factor alpha (TNFα) −G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFα cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFα gene is located as well as association with the −G308A promoter polymorphism. While the common G‐allele shows association in our sample, association with the A‐allele has been reported by other groups. This suggests linkage disequilibrium (LD) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165‐kb region around this polymorphism. We detected nominally significant associations (P |
| doi_str_mv | 10.1002/ajmg.b.30451 |
| format | article |
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Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFα gene is located as well as association with the −G308A promoter polymorphism. While the common G‐allele shows association in our sample, association with the A‐allele has been reported by other groups. This suggests linkage disequilibrium (LD) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165‐kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the −G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (79 sib‐pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30451</identifier><identifier>PMID: 17171665</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult and adolescent clinical studies ; behavioral genetics ; Biological and medical sciences ; complex disorders ; cytokines ; Family ; Gene Frequency ; General aspects ; Genes, MHC Class I ; Genetic Markers ; Haplotypes ; Humans ; Linkage Disequilibrium ; major histocompatibility complex ; Medical genetics ; Medical sciences ; mental disorders ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Part B, Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.318-324</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4321-ab6741f6d66e657c9221304f70ab3def356e4b7dedb235350d38cf2b882717313</citedby><cites>FETCH-LOGICAL-c4321-ab6741f6d66e657c9221304f70ab3def356e4b7dedb235350d38cf2b882717313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18674699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17171665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morar, B.</creatorcontrib><creatorcontrib>Schwab, S.G.</creatorcontrib><creatorcontrib>Albus, M.</creatorcontrib><creatorcontrib>Maier, W.</creatorcontrib><creatorcontrib>Lerer, B.</creatorcontrib><creatorcontrib>Wildenauer, D.B.</creatorcontrib><title>Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>The association of the tumor necrosis factor alpha (TNFα) −G308A promoter polymorphism with schizophrenia has complemented clinical findings of increased levels of the TNFα cytokine in schizophrenic patients, with some support for a functional consequence of the variant. Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFα gene is located as well as association with the −G308A promoter polymorphism. While the common G‐allele shows association in our sample, association with the A‐allele has been reported by other groups. This suggests linkage disequilibrium (LD) rather than direct involvement in the disorder. In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165‐kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the −G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (79 sib‐pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. © 2006 Wiley‐Liss, Inc.</description><subject>Adult and adolescent clinical studies</subject><subject>behavioral genetics</subject><subject>Biological and medical sciences</subject><subject>complex disorders</subject><subject>cytokines</subject><subject>Family</subject><subject>Gene Frequency</subject><subject>General aspects</subject><subject>Genes, MHC Class I</subject><subject>Genetic Markers</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>major histocompatibility complex</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>mental disorders</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqF0MtP4zAQB2ALseK13DgjX-BEih-xnR6hS8si6IIAgbhYjjNpDGnStVNefz0p7ZYbKx9sS9_M2D-EdijpUELYoXkcjzpph5NY0BW0QYVgUZyI-9XlOabraDOER0I4EUqtoXWq2iWl2EBXJ8-mnJrG1RWuc2xCqK1bXq-HlwG7CjcF4JthH5tyUhg8ggqwh9EMvbimwMEW7r2eFB4qZ36iH7kpA2wv9i102z-56Z1G538Gv3tH55GNOaORSaWKaS4zKUEKZbuM0fYPuSIm5RnkXEiIU5VBljIuuCAZT2zO0iRh7eM55Vtof9534uu_UwiNHrtgoSxNBfU0aEU4EwmJ_wtpN5FMSNHCgzm0vg7BQ64n3o2Nf9OU6FnWepa1TvVn1i3fXfSdpmPIvvAi3BbsLYAJ1pS5N5V14cslbQKy220dn7sXV8Lbt0P10dnF4N_4aF7lQgOvyyrjn7RUXAl9Nxzo_rH89XBxfaXv-Qfj3aWh</recordid><startdate>20070405</startdate><enddate>20070405</enddate><creator>Morar, B.</creator><creator>Schwab, S.G.</creator><creator>Albus, M.</creator><creator>Maier, W.</creator><creator>Lerer, B.</creator><creator>Wildenauer, D.B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070405</creationdate><title>Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia</title><author>Morar, B. ; Schwab, S.G. ; Albus, M. ; Maier, W. ; Lerer, B. ; Wildenauer, D.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4321-ab6741f6d66e657c9221304f70ab3def356e4b7dedb235350d38cf2b882717313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>behavioral genetics</topic><topic>Biological and medical sciences</topic><topic>complex disorders</topic><topic>cytokines</topic><topic>Family</topic><topic>Gene Frequency</topic><topic>General aspects</topic><topic>Genes, MHC Class I</topic><topic>Genetic Markers</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>major histocompatibility complex</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>mental disorders</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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In order to define LD of DNA variants with the disorder in this area, we analyzed 36 SNPs in a 165‐kb region around this polymorphism. We detected nominally significant associations (P < 0.05) of three markers (including the −G308A promoter polymorphism) and multiple haplotypes with schizophrenia in our sample of 204 families (79 sib‐pairs and 125 trios). The association is largely restricted to a 30 kb high LD region/block and should assist in the identification of a schizophrenia susceptibility gene within the block or elsewhere in the MHC. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17171665</pmid><doi>10.1002/ajmg.b.30451</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies behavioral genetics Biological and medical sciences complex disorders cytokines Family Gene Frequency General aspects Genes, MHC Class I Genetic Markers Haplotypes Humans Linkage Disequilibrium major histocompatibility complex Medical genetics Medical sciences mental disorders Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Tumor Necrosis Factor-alpha - genetics |
| title | Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia |
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