The MAOA T941G polymorphism and short-term treatment response to mirtazapine and paroxetine in major depression

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2007-04, Vol.144B (3), p.325-331
• Main Authors: Tadić, André, Müller, Matthias J., Rujescu, Dan, Kohnen, Ralf, Stassen, Hans H., Dahmen, Norbert, Szegedi, Armin
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressive Agents - therapeutic use; Biological and medical sciences; Depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; Double-Blind Method; Female; Gene Frequency; Genetic Linkage; Genotype; Humans; major depression; Male; MAOA polymorphism; Medical genetics; Medical sciences; Mianserin - analogs & derivatives; Mianserin - therapeutic use; Middle Aged; mirtazapine; Miscellaneous; Monoamine Oxidase - genetics; Mood disorders; paroxetine; Paroxetine - therapeutic use; Polymorphism, Single Nucleotide; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Sex Characteristics; Time Factors; Treatment Outcome; treatment response
• ISSN: 1552-4841; 1552-485X
• DOI: 10.1002/ajmg.b.30462

This study investigated the possible association of the MAOA T941G gene variant with differential antidepressant response to mirtazapine and/or paroxetine in 102 patients with major depression (DSM‐IV criteria) participating in a randomized double‐blind controlled clinical trial. Female mirtazapine‐treated patients homozygous for the T‐allele had a significantly faster and better treatment response than TG/GG‐patients. In males, we failed to show an association between MAOA T941G gene variant and mirtazapine response. In the paroxetine‐treated group, there were no significant differences in treatment response between MAOA T941G genotype groups. Time course of response and antidepressant efficacy of mirtazapine, but not paroxetine, seem to be influenced in a clinically relevant manner by this allelic variation within the MAOA gene, at least in female patients. An independent replication of our finding is needed. If replicated, genotyping of this locus could become a promising tool to predict response to mirtazapine treatment in females suffering from major depression. © 2006 Wiley‐Liss, Inc.