Thoracic aorta atherosclerosis burden index predicts coronary artery disease in patients undergoing transesophageal echocardiography

Abstract Aims The severity of thoracic aortic atherosclerosis (TAA) is associated with the extent of coronary artery disease (CAD). The aim of this study is to quantitative this relationship by developing a novel atherosclerotic index. Methods and results Two hundred and forty six consecutive patien...

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Bibliographic Details
Published in:Atherosclerosis 2008-03, Vol.197 (1), p.232-236
Main Authors: Frogoudaki, Alexandra, Barbetseas, John, Aggeli, Constadina, Panagiotakos, Demosthenes, Lambrou, Spyros, Pitsavos, Christos, Stefanadis, Christodoulos
Format: Article
Language:English
Subjects:
Adult
Aged
Aorta, Thoracic - diagnostic imaging
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - diagnostic imaging
Atherosclerosis - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary heart disease
Echocardiography, Transesophageal
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Thoracic aorta atherosclerosis
Transesophageal echocardiography
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Summary:Abstract Aims The severity of thoracic aortic atherosclerosis (TAA) is associated with the extent of coronary artery disease (CAD). The aim of this study is to quantitative this relationship by developing a novel atherosclerotic index. Methods and results Two hundred and forty six consecutive patients underwent transesophageal echocardiography (TEE) and coronary angiography. A grading system was used to define the extent of TAA for individual segment of the thoracic aorta. TAA burden index (TAABI) was defined as the sum of the grading for each segment. Of the derived values TAABI had the greatest specificity and sensitivity in predicting CAD. A TAABI of greater than 6 was associated with 16-fold increase in the probability of CAD with a specificity of 88% and a sensitivity of 81%. The positive predictive value was 77% and the negative predictive value 90%. Conclusion A TAABI value of greater than 6 accurately predicts the presence of CAD. Patients with no or mild TAA are at low risk of having angiographically significant CAD.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2007.03.041