The pregnancy-induced increase of plasma angiotensin-(1–7) is blunted in gestational diabetes

• Published in: Regulatory peptides 2007-06, Vol.141 (1), p.55-60
• Main Authors: Nogueira, Anelise Impellizzeri, Souza Santos, Robson Augusto, Simões e Silva, Ana Cristina, Cabral, Antônio Carlos Vieira, Vieira, Renata Lúcia Pereira, Drumond, Thaís Costa, Machado, Lucas José de Campos, Freire, Cláudia Maria Vilas, Ribeiro-Oliveira, Antônio
• Format: Article
• Language: English
• Subjects: Adult; Angiotensin I - blood; Angiotensin II; Angiotensin II - blood; Angiotensin-(1–7); Biological and medical sciences; Case-Control Studies; Diabetes, Gestational - blood; Diabetes, Gestational - diagnosis; Diabetes, Gestational - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Gestational Age; Gestational diabetes; Humans; Peptide Fragments - blood; Pregnancy; Pregnancy Complications, Cardiovascular - blood; Pregnancy Trimester, Third; Radioimmunoassay; Renin-Angiotensin System - physiology; Renin–angiotensin system; Vertebrates: endocrinology
• ISSN: 0167-0115; 1873-1686
• DOI: 10.1016/j.regpep.2006.12.014

It has been shown that the circulating Renin–Angiotensin System (RAS) is activated during normal pregnancy, but little is known about RAS in pregnancies complicated by gestational diabetes (GDM). GDM is considered not merely a temporary condition, but a harbinger of hypertension and type 2 diabetes. The aim of this study was to evaluate the circulating RAS profile in normotensive women with GDM at the third trimester of pregnancy and to compare the results with healthy pregnant and non-pregnant age-matched women. The diagnostic criteria for GDM followed the recommendations of the American Diabetes Association. Angiotensin I (Ang I), Angiotensin II (Ang II) and Angiotensin 1–7 [Ang-(1–7)] were determined in 24 pregnant patients with GDM; 12 healthy pregnant women and 12 non-pregnant women by radioimmunoassay. Levels of Ang I, Ang II and Ang-(1–7) were higher in pregnant women ( p < 0.05), but showed a different pattern in the GDM group, in which reduced Ang-(1–7) circulating levels were found ( p < 0.05). This observation was confirmed by the significantly lower Ang-(1–7)/Ang I ratio ( p < 0.05). Our data suggest that reduced levels of the vasodilator Ang-(1–7) could be implicated in the endothelial dysfunction seen in gestational diabetic women during and after pregnancy.