Endometrial and subendometrial vascularity is higher in pregnant patients with livebirth following ART than in those who suffer a miscarriage

BACKGROUND Blood flow towards the peri-implantation endometrium may have effects on miscarriage and live birth following assisted reproduction treatment, in addition to its role in implantation. METHODS Three-dimensional ultrasound examination with power Doppler was performed on the day of oocyte re...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2007-04, Vol.22 (4), p.1134-1141
Main Authors: Ng, Ernest Hung Yu, Chan, Carina Chi Wai, Tang, Oi Shan, Yeung, William Shu Biu, Ho, Pak Chung
Format: Article
Language:English
Subjects:
3D power Doppler
Abortion, Spontaneous
Adult
Biological and medical sciences
Blastomeres
Embryo Transfer
endometrial and subendometrial vascularity
Endometrium - blood supply
Endometrium - pathology
Female
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
live birth
Medical sciences
miscarriage
Pregnancy
Pregnancy Outcome
Reproductive Techniques, Assisted
ROC Curve
Sensitivity and Specificity
Time Factors
Ultrasonography, Doppler
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Summary:BACKGROUND Blood flow towards the peri-implantation endometrium may have effects on miscarriage and live birth following assisted reproduction treatment, in addition to its role in implantation. METHODS Three-dimensional ultrasound examination with power Doppler was performed on the day of oocyte retrieval in stimulated IVF cycles and on LH + 1 day in frozen thawed-embryo transfer (FET) cycles to measure endometrial thickness, endometrial pattern, uterine artery Doppler flow indices, endometrial volume, vascularization index (VI), flow index (FI), vascularization flow index (VFI) of endometrial and subendometrial regions. RESULTS In stimulated IVF cycles, 45 (28.0%) out of 161 pregnant patients subsequently miscarried. Patients in the live birth group had significantly higher endometrial VI and VFI and subendometrial VI, FI and VFI, when compared with those in the miscarriage group. In a multiple logistic regression analysis, only endometrial VI was significantly associated with the chance of live birth with an odds ratio of 1.384 [95% confidence interval (CI) 1.025–1.869, P = 0.034]. For FET cycles, patients in the live birth group had significantly higher endometrial VFI, subendometrial VI and VFI than those in the miscarriage group. CONCLUSIONS Endometrial and subendometrial vascularity was significantly higher in pregnant patients with live birth following stimulated IVF and FET treatment than in those who suffered a miscarriage.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/del458