Early impairment of left ventricular function in hypercholesterolemia and its reversibility after short term treatment with rosuvastatin A preliminary echocardiographic study

Hypercholesterolemia contributes to coronary heart disease but little is known about its direct effect on myocardial function. We evaluated left ventricular function using echocardiography and the effect of treatment with rosuvastatin in a group of patients with primary hypercholesterolemia. Thirty-...

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Published in:Atherosclerosis 2008-03, Vol.197 (1), p.346-354
Main Authors: TALINI, Enrica, DI BELLO, Vitantonio, MICCOLI, Roberto, BIANCHI, Cristina, PALAGI, Caterina, DELLE DONNE, Maria Grazia, PENNO, Giuseppe, NARDI, Carmela, CANALE, Maria Laura, DEL PRATO, Stefano, MARIANI, Mario
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity
Cardiology. Vascular system
Cardiovascular system
Densitometry
Diastole
Echocardiography, Doppler, Color
Fluorobenzenes - administration & dosage
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hypercholesterolemia - complications
Hypercholesterolemia - drug therapy
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pilot Projects
Pyrimidines - administration & dosage
Rosuvastatin Calcium
Sulfonamides - administration & dosage
Systole
Vasodilator agents. Cerebral vasodilators
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - drug therapy
Ventricular Dysfunction, Left - etiology
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Summary:Hypercholesterolemia contributes to coronary heart disease but little is known about its direct effect on myocardial function. We evaluated left ventricular function using echocardiography and the effect of treatment with rosuvastatin in a group of patients with primary hypercholesterolemia. Thirty-three patients with primary hypercholesterolemia (HC) and without evidence of coronary heart disease and 25 aged matched healthy volunteers (C) were submitted to conventional echocardiography, pulsed wave tissue Doppler imaging (PWTDI), color Doppler myocardial imaging (CDMI) and integrated backscatter (IBS). Echocardiographic evaluation was repeated after 6 months of treatment with rosuvastatin (10mg/day) in 17 patients. Compared with C, patients with HC showed lower E/A ratio (p
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2007.05.024