Hypothyroidism among pediatric cancer patients: A nationwide, registry‐based study

The aim of the study was to determine the incidence and prevalence of hypothyroidism (HT) among childhood cancer survivors by means of register linkage. Patients extracted from the Finnish Cancer Registry data base (5,180 patients with cancer diagnosis at the age of 0–15 years, and born after 1970)...

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Bibliographic Details
Published in:International journal of cancer 2008-04, Vol.122 (8), p.1868-1872
Main Authors: Madanat, Laura‐Maria S., Lähteenmäki, Päivi M., Hurme, Saija, Dyba, Tadeusz, Salmi, Toivo T., Sankila, Risto
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
cancer
Child
Child, Preschool
Endocrinopathies
Female
Finland - epidemiology
Follow-Up Studies
Humans
hypothyroidism
Hypothyroidism - drug therapy
Hypothyroidism - epidemiology
Hypothyroidism - etiology
Incidence
Infant
Infant, Newborn
Insurance, Health
late‐effect
Male
Medical Record Linkage
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - complications
Neoplasms - epidemiology
Neoplasms - therapy
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Prevalence
Proportional Hazards Models
Registries
Sex Distribution
Survivors - statistics & numerical data
Thyroid Function Tests
Thyroid. Thyroid axis (diseases)
thyroxin
Thyroxine - administration & dosage
Thyroxine - economics
Thyroxine - therapeutic use
Tumors
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Summary:The aim of the study was to determine the incidence and prevalence of hypothyroidism (HT) among childhood cancer survivors by means of register linkage. Patients extracted from the Finnish Cancer Registry data base (5,180 patients with cancer diagnosis at the age of 0–15 years, and born after 1970) were linked with thyroxin reimbursement data (Drug Reimbursement Register) and with thyroxin purchase data (prescription database) maintained by the Social Insurance Institution. At the end of follow‐up, the prevalence of HT (10,509/100,000) was found to exceed that in the general population (240/100,000) for those aged
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.23277