Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation

Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation Peter B. Sick, Gerhard Schuler, Karl Eugen. Hauptmann, Eberhard Grube, Steve Yakubov, Zoltan G. Turi, Gregory Mishkel, Steve Almany, David R. Holmes In atrial fibrillation (AF)-re...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-04, Vol.49 (13), p.1490-1495
Main Authors: Sick, Peter B., MD, Schuler, Gerhard, MD, Hauptmann, Karl Eugen, MD, Grube, Eberhard, MD, FACC, Yakubov, Steve, MD, FACC, Turi, Zoltan G., MD, FACC, Mishkel, Gregory, MD, FACC, Almany, Steve, MD, FACC, Holmes, David R., MD, FACC
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aspirin
Atrial Appendage
Atrial Fibrillation - complications
Blood clots
Cardiac arrhythmia
Cardiology
Cardiovascular
Catheters
Diabetes
Disease prevention
Drug therapy
Feasibility Studies
Female
Follow-Up Studies
Global Health
Humans
Hypertension
Internal Medicine
Male
Medical imaging
Middle Aged
Molecular weight
Pilot Projects
Prostheses and Implants
Prosthesis Design
Risk assessment
Stroke
Stroke - etiology
Stroke - prevention & control
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Summary:Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation Peter B. Sick, Gerhard Schuler, Karl Eugen. Hauptmann, Eberhard Grube, Steve Yakubov, Zoltan G. Turi, Gregory Mishkel, Steve Almany, David R. Holmes In atrial fibrillation (AF)-related strokes, if thrombus formation is present in left atrium, more than 90% are in the appendage. This represents the first worldwide experience with the WATCHMAN Left Atrial Appendage System (Atritech Inc., Plymouth, Minnesota). Major adverse events such as pericardial effusions, air embolism, and device embolizations occurred primarily with a first-generation version of the device and during operator learning curves. Device-related thrombus formation in 4 patients resolved with additional anticoagulation. There were no strokes during follow-up despite discontinuation of anticoagulation. Preliminary data suggest the WATCHMAN System to be a safe and feasible approach to sealing of the LAA in AF.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.02.035