The effects of a midbrain glioma on memory and other functions: A longitudinal single case study

Our understanding of the effects of midbrain damage on cognition is largely based on animal studies, though there have been occasional investigations of the effects of human midbrain lesions on cognition. This investigation of a rare case of a glioma initially confined to the dorsal midbrain explore...

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Bibliographic Details
Published in:Neuropsychologia 2008-01, Vol.46 (4), p.1135-1150
Main Author: Weddell, Rodger A.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Arousal
Attention
Biological and medical sciences
Brain
Brain Hemisphere Functions
Brain Stem Neoplasms - pathology
Brain Stem Neoplasms - physiopathology
Cancer
Cognition
Glioma - pathology
Glioma - physiopathology
Humans
Intellect
Intelligence Quotient
Lesion
Long Term Memory
Longitudinal Studies
Magnetic Resonance Imaging
Male
Medical sciences
Memory
Memory - physiology
Midbrain
Motor
Neurological Impairments
Neurology
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time
Retrospective Studies
Schemata (Cognition)
Short Term Memory
Space Perception
Spatial Ability
Tumors of the nervous system. Phacomatoses
Tumour
Verbal Ability
Verbal Behavior
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Summary:Our understanding of the effects of midbrain damage on cognition is largely based on animal studies, though there have been occasional investigations of the effects of human midbrain lesions on cognition. This investigation of a rare case of a glioma initially confined to the dorsal midbrain explores the effects of disease progression on IQ, memory, and choice reaction time. Extensive dorsal midbrain damage did not appear to affect IQ and various memory functions (including span, working memory, story recall, and remote memory). Choice reaction time latencies increased, while verbal and spatial learning and long-term memory deteriorated with tumour growth, but it was not clear how far the deterioration reflected midbrain damage or damage outside the midbrain.
ISSN:0028-3932
1873-3514
DOI:10.1016/j.neuropsychologia.2007.10.016