Osmotic Pressure and Vasculature of Gingiva in Experimental Diabetes Mellitus

Background: Alterations in tissue osmotic pressure (OP) and vasculature are considered to be the inevitable aspects of an inflammatory process that subsequently alter the fluid dynamics of the tissues involved. The aim of this study was to reveal a profile of OP and vascular changes in periodontally...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2007-04, Vol.78 (4), p.757-763
Main Authors: Sakallıoğlu, Elif Eser, Ayas, Bülent, Sakallıoğlu, Umur, Yavuz, Ümit, Açıkgöz, Gökhan, Fıratlı, Erhan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dentistry
Diabetes mellitus
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Facial bones, jaws, teeth, parodontium: diseases, semeiology
gingiva
Gingiva - blood supply
Gingiva - chemistry
Medical sciences
Non tumoral diseases
Osmotic Pressure
Otorhinolaryngology. Stomatology
Rats
tissue
vasculature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Alterations in tissue osmotic pressure (OP) and vasculature are considered to be the inevitable aspects of an inflammatory process that subsequently alter the fluid dynamics of the tissues involved. The aim of this study was to reveal a profile of OP and vascular changes in periodontally healthy gingival tissues and analyze the relationship between them in diabetes mellitus (DM) to evaluate the possible effects of DM on the fluid dynamics of the periodontium. Methods: Experimental DM was created by intraperitoneal streptozotocin injection in 10 periodontally healthy rats. These rats were used as the test group, and 10 systemically and periodontally healthy rats served as the control group. Gingival tissue samples obtained from the groups were used for the test procedures. OP was measured in the supernatants of these samples by a semimicrodigital osmometer. Vasculature was assessed as the alterations in vascularization (vessel number [VN]) and vasodilatation (vessel diameter [VD]) by histomorphometric means. Results: There was a gross increase in the OP level of the test group (172.7 ± 59.7 mOsm/kg) compared to the control group (11.4 ± 4.2 mOsm/kg; P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2007.060332