Impairment of health‐related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety

• Published in: Alimentary pharmacology & therapeutics 2008-04, Vol.27 (7), p.561-571
• Main Authors: HAAG, S., SENF, W., HÄUSER, W., TAGAY, S., GRANDT, D., HEUFT, G., GERKEN, G., TALLEY, N. J., HOLTMANN, G.
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Anxiety Disorders - classification; Anxiety Disorders - complications; Biological and medical sciences; Chronic Disease; Depression; Depressive Disorder - classification; Depressive Disorder - complications; Digestive system; Dyspepsia - classification; Dyspepsia - psychology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver Diseases - classification; Liver Diseases - diagnosis; Liver Diseases - psychology; Male; Medical sciences; Middle Aged; Mood disorders; Other diseases. Semiology; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Quality of Life; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surveys and Questionnaires
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2008.03619.x

Summary Background  Health‐related quality of life (HRQOL) is a marker of disease severity. Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet. Aim  To assess predictors for, and the impairment of, HRQOL in CLD and FD. Methods  In 181 functional dyspepsia (FD) patients, 204 CLD patients and 337 healthy blood donors, HRQOL was assessed with the Short Form‐36 (mental and physical component), and anxiety and depression utilizing the Hospital Anxiety and Depression Scale. Results  Compared with HC, HRQOL is significantly lower in FD and CLD (P‐value for all