The association between coeliac disease and cardiovascular disease

Summary Background  Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear. Aim  To investigate whether coeliac disease patients have an increased risk of cardiovascular events. Methods  A community‐based cohort...

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Published in:Alimentary pharmacology & therapeutics 2008-03, Vol.27 (6), p.514-519
Main Authors: WEI, L., SPIERS, E., REYNOLDS, N., WALSH, S., FAHEY, T., MACDONALD, T. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Celiac Disease - complications
Celiac Disease - epidemiology
Child
Child, Preschool
Digestive system
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infant
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pharmacology. Drug treatments
Scotland - epidemiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Summary Background  Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear. Aim  To investigate whether coeliac disease patients have an increased risk of cardiovascular events. Methods  A community‐based cohort study using a record‐linkage database. Three hundred and sixty‐seven coeliac patients identified by a positive antiendomysial antibody test or a diagnosis with small bowel biopsy, and 5537 subjects who were tested and had a negative coeliac immunology, were included in the study. Results  The crude rates of cardiovascular events were 9.5 per 1000 person‐years (95% CI: 4.4–14.6) in the coeliac cohort and 8.9 per 1000 person‐years (95% CI: 7.6–10.3) in the antiendomysial antibody‐negative cohort. Compared with the antiendomysial antibody‐negative cohort, the adjusted relative risk of cardiovascular events for coeliac cohort was 1.9 (95% CI: 1.00–3.60). When we excluded patients who had previous hospitalization for cardiovascular disease, the adjusted relative risk was 2.5 (95% CI: 1.22–5.01). The use of any cardiovascular drugs prior to and after entry to the study were 36% and 29% for the coeliac cohort (P = 0.05), and 34% and 26% for the antiendomysial antibody‐negative cohort (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2007.03594.x