Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model

Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein e...

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Bibliographic Details
Published in:Neuroscience letters 2007-04, Vol.416 (3), p.252-256
Main Authors: Mu, Jun, Xie, Peng, Yang, Ze-Song, Yang, De-Lan, Lv, Fa-Jin, Luo, Tian-You, Li, Yong
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Depression - pathology
Disease Models, Animal
Electrophoresis, Gel, Two-Dimensional - methods
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - physiology
Hippocampus
Hippocampus - metabolism
Hippocampus - physiopathology
Isoelectric Focusing - methods
Major depression disorders
MALDI-TOF-MS
Male
Neurons - physiology
Organogenesis
Proteomics
Proteomics - methods
Rats
Rats, Sprague-Dawley
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein expression in the hippocampus of a rat depression model. Our results suggest that neurogenesis in hippocampus may play an important role in the pathogenesis of major depression.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2007.01.067