Matrix metalloproteinases in peripheral vascular disease

Matrix metalloproteinases (MMPs) are extracellular matrix–modifying enzymes that are important in many physiologic and pathologic vascular processes. Dysregulation of MMP activity has been associated with common vascular diseases such as atherosclerotic plaque formation, abdominal aortic aneurysms,...

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Bibliographic Details
Published in:Journal of vascular surgery 2007-04, Vol.45 (4), p.849-857
Main Authors: Hobeika, Mark J., MD, Thompson, Robert W., MD, Muhs, Bart E., MD, Brooks, Peter C., PhD, Gagne, Paul J., MD
Format: Article
Language:English
Subjects:
Animals
Aortic Aneurysm, Abdominal - drug therapy
Aortic Aneurysm, Abdominal - enzymology
Atherosclerosis - drug therapy
Atherosclerosis - enzymology
Biomarkers - metabolism
Constriction, Pathologic - drug therapy
Constriction, Pathologic - enzymology
Constriction, Pathologic - surgery
Enzyme Inhibitors - pharmacology
Enzyme Inhibitors - therapeutic use
Extremities - blood supply
Humans
Ischemia - drug therapy
Ischemia - enzymology
Matrix Metalloproteinases, Secreted - antagonists & inhibitors
Matrix Metalloproteinases, Secreted - metabolism
Peripheral Vascular Diseases - diagnosis
Peripheral Vascular Diseases - drug therapy
Peripheral Vascular Diseases - enzymology
Recurrence
Surgery
Tissue Inhibitor of Metalloproteinases - metabolism
Varicose Ulcer - drug therapy
Varicose Ulcer - enzymology
Varicose Veins - drug therapy
Varicose Veins - enzymology
Vascular Surgical Procedures - adverse effects
Venous Thrombosis - drug therapy
Venous Thrombosis - enzymology
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Description
Summary:Matrix metalloproteinases (MMPs) are extracellular matrix–modifying enzymes that are important in many physiologic and pathologic vascular processes. Dysregulation of MMP activity has been associated with common vascular diseases such as atherosclerotic plaque formation, abdominal aortic aneurysms, and critical limb ischemia. For this reason, MMPs have become an important focus for basic science studies and clinical investigations by vascular biology researchers. This article reviews the recent literature, summarizing our current understanding of the role of MMPs in the pathogenesis of various peripheral vascular disease states. In addition, the importance of MMPs in the future diagnosis and treatment of peripheral vascular disease is discussed.
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2006.09.066