Fibrinogen γ' in Ischemic Stroke : A Case-Control Study

• Published in: Stroke (1970) 2008-03, Vol.39 (3), p.1033-1035
• Main Authors: CHEUNG, Elim Y. L, UITTE DE WILLIGE, Shirley, VOS, Hans L, LEEBEEK, Frank W. G, DIPPEL, Diederik W. J, BERTINA, Rogier M, DE MAAT, Moniek P. M
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alleles; Biological and medical sciences; Brain Ischemia - complications; Case-Control Studies; Female; Fibrinogens, Abnormal - metabolism; Genetic Variation; Haplotypes; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Heterozygote; Humans; Ischemic Attack, Transient - blood; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Polymorphism, Single Nucleotide; Stroke - blood; Stroke - etiology; Stroke - prevention & control; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.107.495499

To determine the contribution of fibrinogen gamma' levels and FGG haplotypes to ischemic stroke. Associations between fibrinogen gamma' levels, fibrinogen gamma'/total fibrinogen ratio, and FGG haplotypes with the risk of ischemic stroke were determined in 124 cases and 125 controls. Fibrinogen gamma'/total fibrinogen ratio was higher in patients than in controls during the acute phase of the stroke and lower in the convalescent phase 3 months after the stroke. FGG haplotype 3 (H3) was associated with a reduced risk of ischemic stroke (odds ratio 0.60; 95% CI, 0.38 to 0.94), but not with the fibrinogen gamma'/total fibrinogen ratio. In contrast, FGG-H2 was associated with a decreased fibrinogen gamma'/total fibrinogen ratio, but not with risk of stroke. Fibrinogen gamma'/total fibrinogen ratio is associated with ischemic stroke, especially in the acute phase of the disease. In addition, FGG-H3 haplotype appears to be protective against ischemic stroke.