Spectrophotometric simultaneous determination of Rabeprazole Sodium and Itopride Hydrochloride in capsule dosage form

A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the cor...

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Bibliographic Details
Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2008-03, Vol.69 (3), p.849-852
Main Authors: Sabnis, Shweta S., Dhavale, Nilesh D., Jadhav, Vijay. Y., Gandhi, Santosh V.
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles - analysis
Benzamides - analysis
Benzyl Compounds - analysis
Capsules - chemistry
Itopride hydrochloride
Rabeprazole
Rabeprazole sodium
Ratio spectra derivative spectrophotometry
Reference Standards
Solutions
Spectrophotometry, Ultraviolet
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Summary:A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the corresponding ratio spectra at 231 nm (minima) and 260 nm were selected to determine rabeprazole sodium and itopride hydrochloride, respectively. The method was validated with respect to linearity, precision and accuracy.
ISSN:1386-1425
DOI:10.1016/j.saa.2007.05.048